EFFECTS OF CONCURRENT TRAINING ON MUSCLE SATELLITE CELLS AND MYOFIBRILLAR PROTEIN SYNTHESIS

• Grant number: 16/09759-8
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2016
• End date: March 31, 2019
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Ugrinowitsch
• Grantee: Carlos Ugrinowitsch
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Cleiton Augusto Libardi ; Hamilton Augusto Roschel da Silva ; Valmor Alberto Augusto Tricoli

Abstract

Problem: Can satellite cells (SC) and myofibrilar protein synthesis (MPS) explain the lower muscle gains after concurrent training (CT) compared to resistance training (RT) alonere. Main: to compare muscle fiber hypertrophy, number of SC and myonuclei and the MPS after 16 weeks of CT and RT. Methods: 20 young male subjects will be allocated in one of the following groups: concurrent training (CT, n=10) or resistance training (RT, n=10). The RT group will perform Leg press, leg extension and leg Curl, 5x8-12 maximum repetitions with 90s of rest, 3x per week. The CT group will perform the same RT protocol followed by a running exercise, 5 sprints of 4 min at an intensity of 85% of VO2máx with 3 min of rest between sets. The subjects will undergo for 3 muscle samples, 2 blood samples, 6 salive samples before and after the first and last training session and 1 muscle strength test and maximum oxygen intake test (VO2máx) before and after experimental period. After experimental period, the MPS (determined by ²H2O) and SC analyses will be performed for the team of Professor John A. Hawley of Australian Catholic University, Australia, that is an expert in both analyses. Thus, I believe that I have necessary conditions to understand the physiological mechanisms that can clarify why the muscle hypertrophy is smaller after CT compared RT alone. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIXANDRAO, MANOEL E.; UGRINOWITSCH, CARLOS; BERTON, RICARDO; VECHIN, FELIPE C.; CONCEICAO, MIGUEL S.; DAMAS, FELIPE; LIBARDI, CLEITON A.; ROSCHEL, HAMILTON. Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis. SPORTS MEDICINE, v. 48, n. 2, p. 361-378, FEB 2018. (16/09759-8, 16/10993-5, 16/22635-6)

CONCEICAO, MIGUEL S.; VECHIN, FELIPE C.; LIXANDRAO, MANOEL; DAMAS, FELIPE; LIBARDI, CLEITON A.; TRICOLI, VALMOR; ROSCHEL, HAMILTON; CAMERA, DONNY; UGRINOWITSCH, CARLOS. Muscle Fiber Hypertrophy and Myonuclei Addition: A Systematic Review and Meta-analysis. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 7, p. 1385-1393, JUL 2018. (16/09759-8, 15/19756-3)

CONCEICAO, MIGUEL S.; UGRINOWITSCH, CARLOS. Exercise with blood flow restriction: an effective alternative for the non-pharmaceutical treatment for muscle wasting. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v. 10, n. 2, p. 6-pg., 2019-04-01. (16/09759-8, 15/19756-3)