Role of the redox environment and protein tyrosine phosphatase oxidation in atherosclerotic plaque vulnerability

• Grant number: 16/50183-2
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2016
• End date: November 30, 2018
• Field of knowledge: Biological Sciences - Pharmacology - Cardiorenal Pharmacology
• Agreement: University of Glasgow
• Principal Investigator: Rita de Cassia Aleixo Tostes Passaglia
• Grantee: Rita de Cassia Aleixo Tostes Passaglia
• Principal researcher abroad: Rhian Touyz
• Institution abroad: University of Glasgow, Scotland
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The present project focuses on vascular oxidative stress as a mechanistic link between macrophage infiltration, matrix metalloproteinase activation and VSMC dysregulation (apoptosis) in atherosclerotic plaque instability. We aim to determine how the vascular redox environment impacts the atherosclerotic plaque phenotype. In particular we will unravel the role of PTPs in this process. (AU)