Implementation, evaluation and comparison of contraction force models and / or shortening for rat ventricular myocite

• Grant number: 16/18422-7
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2017
• End date: August 31, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Robson Rodrigues da Silva
• Grantee: Robson Rodrigues da Silva
• Host Institution: Pró-Reitoria Acadêmica. Universidade de Mogi das Cruzes (UMC). Campus da Sede Mogi das Cruzes. Mogi das Cruzes , SP, Brazil
• Associated researchers: Jose Wilson Magalhaes Bassani ; Rosana Almada Bassani

Abstract

According to World Health Organization data, cardiovascular disease, including heart arrhythmias, account for about 17.5 million annual deaths worldwide, and 80% of these deaths occur in developing countries, including Brazil. These data point to the need to increasingly understand the complex phenomenon of the coupling of excitation - contraction of the cardiac cell, allowing not only the prevention of diseases such as proper treatment from the use of new antiarrhythmic drugs. In this context, the formulation of mathematical and computational models of cardiac electrophysiology and comparison between the results of "in silico" experiments and those "in vitro" or "in vivo" have been able to produce important information not only about the mechanisms of intracellular Ca2+ dynamics but primarily on issues related to force of contraction and cardiac arrhythmias. However, due to the complexity of the contraction mechanism in the cardiac cell, contraction force models, such as those of Negroni and Lascano (1996) and by Rice et al (1999), are based only on the models of cross-bridges of two states described by Huxley in 1957. Thus, taking into account the two main models of contractile force of cardiac cell, the objective of this project is to implement (in a rat ventricular myocyte model), to compare and test (from experimental data) the contraction force models and / or cell shortening to rat ventricular myocytes, providing the scientific community with more information that enables to assess the robustness of these contraction models and, from the analysis of these results, to implement new mechanisms that can better describe this complex electro-mechanical phenomenon of cardiac cell in the near future. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, ANDREW GUIMARAES; SANTOS, B. S.; OLIVEIRA, M. N.; OLIVEIRA, L. J.; GOROSO, D. G.; NAGAI, J.; SILVA, R. R.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Development of a Hydraulic Model of the Microcontrolled Human Circulatory System. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 5-pg., 2022-01-01. (13/20220-5, 16/18422-7)

SILVA, ANDREW GUIMARAES; GOROSO, DANIEL G.; SILVA, ROBSON RODRIGUES; DIAZ, CAG; GONZALEZ, CC; LEBER, EL; VELEZ, HA; PUENTE, NP; FLORES, DL; ANDRADE, AO; et al. SCHSim: A Simulator of Elastic Arterial Vessels Using Windkessel Models. VIII LATIN AMERICAN CONFERENCE ON BIOMEDICAL ENGINEERING AND XLII NATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, v. 75, p. 9-pg., 2020-01-01. (16/18422-7, 13/20220-5)

DA SILVA, ROBSON RODRIGUES; GOROSO, DANIEL GUSTAVO; BERS, DONALD M.; PUGLISI, JOSE LUIS. MarkoLAB: A simulator to study ionic channel's stochastic behavior. COMPUTERS IN BIOLOGY AND MEDICINE, v. 87, p. 258-270, AUG 1 2017. (16/18422-7, 13/20220-5)

DA SILVA, ROBSON RODRIGUES; DE SOUZA FILHO, OSIAS BAPTISTA; MAGALHAES BASSANI, JOSE WILSON; BASSANI, ROSANA ALMADA. The ForceLAB simulator: Application to the comparison of current models of cardiomyocyte contraction. COMPUTERS IN BIOLOGY AND MEDICINE, v. 131, APR 2021. (16/18422-7, 13/20220-5)