Diagnosis of myocardial fibrosis by magnetic resonance imaging (T1 mapping) and histopathological quantification in patients with severe aortic valve disease submitted to conventional surgery and its impact on prognosis

• Grant number: 15/01269-9
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2017
• End date: October 31, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Flávio Tarasoutchi
• Grantee: Flávio Tarasoutchi
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Carlos Eduardo Rochitte ; Cesar Higa Nomura ; Lucas José Neves Tachotti Pires ; Pablo Maria Alberto Pomerantzeff ; Paulo Sampaio Gutierrez

Abstract

Patients with aortic valve regurgitation or stenosis have myocardial hypertrophy mechanisms that include cellular stimuli capable of promoting the formation of diffuse fibrosis. The importance of cardiovascular magnetic resonance (CMR) in the evaluation of myocardial structure and function is already established. A new method for evaluating fibrosis by CMR, called T1 mapping, has been developed. It can quantify with better sensitivity the extracellular myocardial volume, which represents, when increased, the diffuse myocardial fibrosis, in this population. The primary objective of this study is to evaluate the prognostic value of the preoperative quantification of diffuse myocardial fibrosis using T1 mapping (by the quantification of the extracellular distribution volume - EDV) in patients with severe aortic valve disease submitted to surgical treatment. One hundred patients with severe aortic valve stenosis or regurgitation will be included, and will undertake CMR before surgery and 6 to 9 months after surgery. The CMR data will be compared to the pathology data, acquired by intraoperative biopsy. Patients will be followed for 5 years postoperatively, and then the correlation between preoperative quantification of diffuse myocardial fibrosis and overall mortality will be evaluated. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PIRES, LUCAS T.; ROSA, VITOR E. E.; MORAIS, THAMARA C.; BELLO, JULIANA H. S. M.; FERNANDES, JOAO R. C.; DE SANTIS, ANTONIO; LOPES, MARIANA P.; GUTIERREZ, PAULO S.; ROCHITTE, CARLOS E.; NOMURA, CESAR H.; et al. Postoperative myocardial fibrosis assessment in aortic valvular heart diseases-a cardiovascular magnetic resonance study. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, v. 24, n. 7, p. 12-pg., 2023-03-20. (15/01269-9)