Experimental and computational assays on molecular targets with pharmacological importance and interactions with natural products

• Grant number: 17/08834-9
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2017
• End date: October 31, 2019
• Field of knowledge: Biological Sciences - Biophysics - Molecular Biophysics
• Principal Investigator: Marinônio Lopes Cornélio
• Grantee: Marinônio Lopes Cornélio
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
• Associated researchers: Leandro Cristante de Oliveira

Abstract

The Nobel Prize in Physiology and Medicine in 2015 was awarded to researchers William C. Campbell, Satoshi Omura, and You You Tu. The first two by the discovery of the natural product avermictins and its derivative ivermectin, which greatly diminishes the incidence of Onchocerciasis (known as river blindness) and lymphatic Filaria (known as elephantiasis), and to the researcher Youyou Tu for the discovery of the natural product coming Of plant origin artemisinin, which reduces the mortality rate of patients with malaria. These discoveries brought back the scenario of research into new drugs, products originating from microorganisms and natural products (PN). Although the areas of pharmacology and natural products have in their collection multiple experimental techniques for in vivo and in vitro study. However the molecular approach is still restricted. The systematic and joint application of experimental and computational techniques with physical foundation has the capacity to elucidate molecular mechanisms that occur during the interaction process between drugs and molecular targets. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

POVINELLI, ANA PAULA RIBEIRO; ZAZERI, GABRIEL; JONES, ALAN M.; CORNELIO, MARINONIO LOPES. A Computational-Experimental Investigation of the Molecular Mechanism of Interleukin-6-Piperine Interaction. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 14, p. 14-pg., 2022-07-01. (17/08834-9)

POVINELLI, ANA PAULA RIBEIRO; ZAZERI, GABRIEL; JONES, ALAN M.; CORNELIO, MARINONIO LOPES. nravelling the Interaction of Piperlongumine with the Nucleotide-Binding Domain of HSP70: A Spectroscopic and In Silico Stud. PHARMACEUTICALS, v. 14, n. 12, DEC 2021. (17/08834-9)

DE ALCANTARA-CONTESSOTO, NAYARA SOUSA; CARUSO, ICARO PUTINHON; BEZERRA, DANIEL PEREIRA; BARBOSA FILHO, JOSE MARIA; CORNELIA, MARINONIO LOPES. An investigation into the interaction between piplartine (piperlongumine) and human serum albumin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 220, SEP 5 2019. (17/08834-9)

ZAZERI, GABRIEL; POVINELLI, ANA PAULA RIBEIRO; LIMA, MARCELO DE FREITAS; CORNELIO, MARINONIO LOPES. Detailed Characterization of the Cooperative Binding of Piperine with Heat Shock Protein 70 by Molecular Biophysical Approaches. BIOMEDICINES, v. 8, n. 12, DEC 2020. (17/08834-9)

ZAZERI, GABRIEL; RIBEIRO POVINELLI, ANA PAULA; LIMA, MARCELO DE FREITAS; CORNELIO, MARINONIO LOPES. Experimental Approaches and Computational Modeling of Rat Serum Albumin and Its Interaction with Piperine. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 12, JUN 2 2019. (17/08834-9)

ZAZERI, GABRIEL; RIBEIRO POVINELLI, ANA PAULA; LIMA, MARCELO DE FREITAS; CORNELIO, MARINONIO LOPES. The Cytokine IL-1 beta and Piperine Complex Surveyed by Experimental and Computational Molecular Biophysics. BIOMOLECULES, v. 10, n. 9, SEP 2020. (17/08834-9)

CARUSO, ICARO PUTINHON; VILEGAS, WAGNER; DE OLIVEIRA, LEANDRO CRISTANTE; CORNELIO, MARINONIO LOPES. Fluorescence spectroscopic and dynamics simulation studies on isoorientin binding with human serum albumin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v. 228, MAR 5 2020. (17/08834-9)

RIBEIRO POVINELLI, ANA PAULA; ZAZERI, GABRIEL; LIMA, MARCELO DE FREITAS; CORNELIO, MARINONIO LOPES. Details of the cooperative binding of piperlongumine with rat serum albumin obtained by spectroscopic and computational analyses. SCIENTIFIC REPORTS, v. 9, OCT 30 2019. (17/08834-9)