Sweat as a target biological matrix for determination of Fentanyl-derived compounds and synthetic Cathinones

• Grant number: 17/18021-5
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2017
• End date: April 30, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Bruno Spinosa de Martinis
• Grantee: Bruno Spinosa de Martinis
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The emergence and spread of new psychoactive substances throughout the world represents a troubling public health problem. As in cases of intoxication involving already known drugs of abuse, it is necessary to identify and detect these substances in biological fluids. The analytical challenge is to chose the appropriate biological matrix for analysis as well as to develop and to validate a method for detecting these new substances in this matrix. In recent years, sweat has been proposed as an alternative biological matrix and different substances of forensic interest, such as drugs of abuse, have been successfully investigated in this biological fluid, which has advantages over other fluids commonly used in analysis, such as blood and urine. In this sense, the proposal of this project is to explore the analysis of these new psychoactive substances, which is still in sweat, which is still few explored in literature, with the development and validation of an analytical method employing Gas Phase Chromatography coupled to Mass Spectrometry. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE CAMPOS, EDUARDO GERALDO; DA COSTA, BRUNO RUIZ BRANDAO; DOS SANTOS, FABIANA SPINETI; MONEDEIRO, FERNANDA; ALVES, MARCELA NOGUEIRA RABELO; SANTOS JUNIOR, WILSON JOSE RAMOS; DE MARTINIS, BRUNO SPINOSA. Alternative matrices in forensic toxicology: a critical review. Forensic Toxicology, AUG 2021. (17/18021-5, 17/10387-0, 13/19653-4)