Component C5 dependent gene expression in mice ethanol-induced liver injury

• Grant number: 07/03393-2
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: May 01, 2008
• End date: October 31, 2012
• Field of knowledge: Biological Sciences - Immunology - Immunogenetics
• Principal Investigator: Lourdes Isaac
• Grantee: Lorena Bavia
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The complement system is an important component of innate and acquired immune response. It is responsible for known many biologic functions and it is constituted by more than 30 different proteins in a cascade system. Recent studies suggested a key-function of these proteins in the inflammatory process, in which they can modulate cellular responses and interactions, such as lipid metabolism, cellular differentiation and proliferation and hepatic regeneration. In this last condition, C5 and its receptor seems to be highly involved. This role in the liver regeneration is very important, because several homeostatic process depends of the healthy condition of the liver. Moreover, the liver is vulnerable for many metabolite and toxic products. Nowadays, alcoholic consumption is a great healthy problem and cause large hepatic injury. Our aim in this work is investigate the complement proteins influence in the hepatic gene expression and inflammatory responde of C5-deficient mouse treated with/without ethanol. For this, we intend: 1) evaluate the C5-dependent inflammatory response in animals treated with ethanol; 2) access the contribution of complement proteins in the gene expression in liver under physiologic and pathologic conditions, in the C5-deficient murine model. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BAVIA, LORENA. A/J mice are more susceptible than C57BL/6 to acetaminophen-induced hepatotoxicity. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, v. 108, MAR-APR 2021. (07/03393-2)

SANTIESTEBAN-LORES, LAZARA ELENA; CARNEIRO, MILENA CARVALHO; ISAAC, LOURDES; BAVIA, LORENA. Complement System in Alcohol-Associated Liver Disease. Immunology Letters, v. 236, p. 37-50, AUG 2021. (17/12924-3, 19/19800-3, 07/03393-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

BAVIA, Lorena. Contribution of murine complement component C5 in experimental alcoholic fatty liver disease.. 2013. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.