Docking of arilloxazines family compounds in enzymes related with malaria

• Grant number: 07/06125-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2008
• End date: January 31, 2010
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Ignez Caracelli
• Grantee: Denis da Silva Corrêa
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

Docking studies of arilloxazines family compounds and chloroquine will be done to act as inhibitors of the Plasmodium falciparum Glutathione Reductase, Dihydrofolate Reductase-Thymidylate Synthase and Lactate Dehydrogenase enzymes, related with malaria. Also it will be analyzed, through docking studies, the interaction of the same inhibitors with the human Glutathione Reductase, for comparison ends.