Functional and structural characterization of alfa-type phospholipase A2 inhibitor from B. alternatus snake plasma: cloning, expression and mapping of the region responsible for its inhibitory activity

• Grant number: 08/10760-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2009
• End date: November 30, 2012
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Suely Vilela
• Grantee: Norival Alves Santos Filho
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 05/54855-0 - Animal toxins: structure, function and biotechnological applications, AP.TEM

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS-FILHO, NORIVAL A.; SOUSA, TIAGO S.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; CINTRA, ADELIA C. O.; LAURE, HELEN J.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; et al. rBaltMIP, a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus (Rhinocerophis alternatus) snake, as a potential candidate to complement the antivenom therapy. Toxicon, v. 124, p. 53-62, DEC 15 2016. (11/23236-4, 08/10760-4)

SANTOS-FILHO, NORIVAL A.; BOLDRINI-FRANCA, JOHARA; SANTOS-SILVA, LUDIER K.; MENALDO, DANILO L.; HENRIQUE-SILVA, FLAVIO; SOUSA, TIAGO S.; CINTRA, ADELIA C. O.; MAMEDE, CARLA C. N.; OLIVEIRA, FABIO; ARANTES, ELIANE C.; et al. Heterologous expression and biochemical and functional characterization of a recombinant alpha-type myotoxin inhibitor from Bothrops alternatus snake. Biochimie, v. 105, p. 119-128, OCT 2014. (11/23236-4, 08/10760-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS FILHO, Norival Alves. Functional and structural characterization of an α-type phospholipase A2 inhibitor from Bothrops alternatus: Cloning, expression and mapping of the region responsible for its inhibitory activity. 2013. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.