Strategies to improve efficiency of genomic selection in animal breeding programs

• Grant number: 10/06185-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2010
• End date: June 30, 2013
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal Investigator: Sandra Aidar de Queiroz
• Grantee: Haroldo Henrique de Rezende Neves
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

This project involves three different studies to evaluate alternative strategies to improve efficiency of genomic selection in animal breeding programs. The first study will be developed to assess feasibility of using dimension reduction methods to predict genetic merit of animals based on information of genome-wide dense molecular markers, as a computationally efficient alternative that could allow genotyping animals at lower cost. Different scenario will be simulated to investigate influence of underlying QTL distribution and marker density on accuracy of prediction methods. The aim of second study will be to compare predictive ability of methods investigated in first study when using data from a real population of mice, comprising records of three traits with heritabilities of different strength. A third study will be carried out to assess long-term consequences of genomic selection in a simulated population, by measuring genetic gain and inbreeding incidence and comparing these figures with those obtained by conventional selection (based on BLUP). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE REZENDE NEVES, HAROLDO HENRIQUE; CARVALHEIRO, ROBERTO; DE QUEIROZ, SANDRA AIDAR. Trait-specific long-term consequences of genomic selection in beef cattle. Genetica, v. 146, n. 1, p. 85-99, FEB 2018. (10/06185-4)

DE REZENDE NEVES, HAROLDO HENRIQUE; DOS REIS, FELIPE POLIN; PATERNO, FLAVIA MOTTA; GUARINI, ALINE ROCHA; CARVALHEIRO, ROBERTO; DA SILVA, LILIAN REGINA; DE OLIVEIRA, JOAO ADEMIR; DE QUEIROZ, SANDRA AIDAR. Herd-of-origin effect on the post-weaning performance of centrally tested Nellore beef cattle. TROPICAL ANIMAL HEALTH AND PRODUCTION, v. 46, n. 7, p. 1235-1241, OCT 2014. (10/06185-4, 11/16066-5)

NEVES, HAROLDO H. R.; CARVALHEIRO, ROBERTO; PEREZ O'BRIEN, ANA M.; UTSUNOMIYA, YURI T.; DO CARMO, ADRIANA S.; SCHENKEL, FLAVIO S.; SOELKNER, JOHANN; MCEWAN, JOHN C.; VAN TASSELL, CURTIS P.; COLE, JOHN B.; et al. Accuracy of genomic predictions in Bos indicus (Nellore) cattle. GENETICS SELECTION EVOLUTION, v. 46, FEB 27 2014. (10/52030-2, 11/16643-2, 10/06185-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

NEVES, Haroldo Henrique de Rezende. Strategies to improve the efficiency of genomic selection in animal breeding programs. 2013. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.