iPS cells as disease models for inherited cardiomyopathies

• Grant number: 10/13426-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2011
• End date: January 31, 2014
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: José Eduardo Krieger
• Grantee: Diogo Gonçalves Biagi dos Santos
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Cardiomyopathies are responsable for part of the deaths in Heart Failure. Cardomyocytes derived from iPS cells present as a great tool to study cardiomyopathies. As iPS cells can be reprogrammed from any person, it is possible to study cardiomyocytes from patients with genetic mutations responsible for the development of the disease.The aim of this project is to create a patient-specific disease model of Hipertrofic Cardiomyopathy. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Diogo Gonçalves Biagi dos. Induced pluripotent stem cells to study cardiomyocytes derived from patients with genetic cardiomyopathies. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.