Influence of the inflamassoma on the squamous cell carcinoma development in an experimental model

• Grant number: 11/09664-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2011
• End date: October 31, 2012
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Ana Paula Campanelli
• Grantee: Luisa Thomazini de Freitas
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

Chronic inflammation generated by persistent inflammatory stimuli may be related to the development and progression of different tumor types. In the setting of chronic inflammation there is a constant generation and secretion of pro-inflammatory cytokines and chemokines, which facilitates the exacerbation of the lesions. The signals generated by different stimuli (danger signals) induce the production of bioactivities IL-1² and IL-18, which are related with acute and chronic inflammation and can lead to a type of cell death called piroptosis. It is known that the production of these cytokines is induced from the activation of an intracellular structure known as inflamassome. Recently, the role of inflammasome, a molecular complex involved in the inflammatory activation of caspases, has been associated with the exacerbation of the inflammatory response. The involvement of inflammasome in the development and progress of squamous cells carcinoma is not established. Thus, this study aims to examine the role of inflammasome, and the consequent production of IL-1² and IL-18 in the establishment and progression of lesions of squamous cells carcinoma chemically induced in mice.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GASPAROTO, THAIS HELENA; DE OLIVEIRA, CARINE ERVOLINO; DE FREITAS, LUISA THOMAZINI; PINHEIRO, CLAUDIA RAMOS; HORI, JULIANA ISSA; GARLET, GUSTAVO POMPERMAIER; CAVASSANI, KAREN ANGELICA; SCHILLACI, ROXANA; DA SILVA, JOAO SANTANA; ZAMBONI, DARIO SIMOES; et al. Inflammasome Activation Is Critical to the Protective Immune Response during Chemically Induced Squamous Cell Carcinoma. PLoS One, v. 9, n. 9, SEP 30 2014. (11/09664-3, 09/14127-7, 12/15331-0, 11/03195-1)