Correlation between tubule-clusters alterations and the degree of histology mammary neoplasm in bitches

• Grant number: 11/08416-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2011
• End date: June 30, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Áureo Evangelista Santana
• Grantee: Leandro Zuccolotto Crivellenti
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Associated scholarship(s): 12/25515-0 - Externship at The Ohio State University- OSU, United States, BE.EP.DR

Abstract

It is proposed with this essay to evaluate possible glomerular and tubular abnormalities in bitches with mammary cancer in order to investigate possible correlations between the degree of malignancy of mammary cancer and kidney damage. Ten animals will be used for control and 30 bitches with diagnosis of mammary cancer from the Oncology Service of the Veterinary Teaching Hospital "Governador Laudo Natel" of Faculdade de Ciências Agrárias e Veterinárias - UNESP, campus de Jaboticabal. The experimental protocol includes the obtaining of data related to clinical and pathological blood count, serum biochemistry, urinary fractional excretion of sodium and blood pressure. In addition, all bitches with mammary cancer will be submitted to renal biopsy in the occasion of ovariohysterectomy and will also undergo mastectomy. The kidney samples will be evaluated by light microscopy and immunofluorescence at the Laboratório de Patologia Renal da Faculdade de Medicina de Ribeirão Preto (USP). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALOMAO, RICARDO L.; CRIVELLENTI, LEANDRO Z.; SIMOES, ANA PAULA R.; BRITO, MARINA B. S.; SILVA, PALOMA E. S.; COSTA, PAULA B.; TINUCCI-COSTA, MIRELA; SANTANA, AUREO E.; BORIN-CRIVELLENTI, SOFIA. Concentrações séricas de cortisol e tiroxina em cadelas com carcinoma mamário em estádio inicial. Pesquisa Veterinária Brasileira, v. 38, n. 10, p. 1949-1954, OCT 2018. (11/11355-9, 11/08416-6)

MACHADO, VANESSA S.; CRIVELLENTI, LEANDRO Z.; BOTTARI, NATHIELI B.; TONIN, ALEXANDRE A.; PELINSON, LUANA P.; BORIN-CRIVELLENTI, SOFIA; SANTANA, AUREO E.; TORBITZ, VANESSA D.; MORESCO, RAFAEL N.; DUARTE, THIAGO; et al. Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma. PATHOLOGY RESEARCH AND PRACTICE, v. 211, n. 9, p. 677-681, 2015. (11/11355-9, 11/08416-6)

CRIVELLENTI, LEANDRO Z.; SILVA, GYL E. B.; BORIN-CRIVELLENTI, SOFIA; CIANCIOLO, RACHEL; ADIN, CHRISTOPHER A.; DANTAS, MARCIO; DOS ANJOS, DENNER S.; TINUCCI-COSTA, MIRELA; SANTANA, AUREO E.. Prevalence of Glomerulopathies in Canine Mammary Carcinoma. PLoS One, v. 11, n. 10, OCT 20 2016. (11/11355-9, 11/08416-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CRIVELLENTI, Leandro Zuccolotto. Alterações glomérulo-tubulares em cadelas com carcinoma mamário. 2014. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.