IN VITRO BEHAVIOR OF CANINE CARCINOMA CELLS SUBMITTED TO 3D-DIMENSIONAL CULTURE SYSTEM

• Grant number: 11/00613-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2011
• End date: August 31, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Alexandre Lima de Andrade
• Grantee: Daniela Stochmann Silva
• Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Breast cancer in dogs is common among mammals and that the canine species is one of the most affected, and their injuries are known for their heterogeneity. This project has as main objective to study through experimental trials in cultivation "in vitro" in monolayer and in 3 dimensions apoptosis interaction between the proteins p53, p63, Bcl-2 and Bax involved in this process, as well as the enzyme DNA methyltransferase 1 (DNMT1) and the action of the drug Carboplatin in cultivation in 3D. This neoplasm offers a unique opportunity to study the interaction of proteins involved in apoptosis along with the prognosis of breast carcinoma.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Daniela Stochmann. Desenvolvimento do cultivo 3D a partir de células primarias de neoplasias mamárias caninas: estudo da apoptose sobre efeito ou não da carboplatina. 2014. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.