Evaluation of subclinical atherosclerosis in individuals with makedly elevated HDL-cholesterol levels

• Grant number: 11/14201-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2011
• End date: November 30, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Raul Dias dos Santos Filho
• Grantee: Leonardo Mateus de Lima
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Hypercholesterolemia is an important risk factor to cardiovascular disease, and low HDL-c is strongly associated with the development of atherosclerotic disease. Although the current guidelines suggest values above 40mg/dL for men and 50mg/dL for women, there is no evidence which would be the HDL-c to be reached nor the best way to achieve these levels. It is unclear whether the presence of markedly elevated HDL-c plasma level (HALP - hyperalphalipoproteinemia) represents an atherogenic or atheroprotective condition, since these HDL particles may be dysfunctional. The aim of this study is to compare the prevalence of subclinical coronary atherosclerosis, evaluated by coronary computed tomography (calcium score) among patients with HDL-c >90mg/dL (HALP group) and those with normal levels of HDL-c (40 - 50mg/dL for men; 50 - 60mg/dL for women - control group). In addtion the functionability of these HDL particles will be tested regarding their cholesterol efflux capacity and their anti-oxidative properties.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MANGILI, LEONARDO C.; MANGILI, OTAVIO C.; BITTENCOURT, MARCIO S.; MINAME, MARCIO H.; HARADA, PAULO H.; LIMA, LEONARDO M.; ROCHITTE, CARLOS E.; SANTOS, RAUL D.. Epicardial fat is associated with severity of subclinical coronary atherosclerosis in familial hypercholesterolemia. ATHEROSCLEROSIS, v. 254, p. 73-77, NOV 2016. (11/14201-2)

HARADA, PAULO H. N.; CANZIANI, MARIA E.; LIMA, LEONARDO M.; KAMIMURA, MARIA; ROCHITTE, CARLOS E.; LEMOS, MARCELO M.; CUPPARI, LILIAN; KALIL FILHO, ROBERTO; DRAIBE, SERGIO A.; SANTOS, RAUL D.. Pericardial Fat Is Associated with Coronary Artery Calcification in Non-Dialysis Dependent Chronic Kidney Disease Patients. PLoS One, v. 9, n. 12, DEC 5 2014. (11/14201-2)