Antidepressant treatment on rats with subchronic aortic regurgitation: baroreflex function and sodium excretion

• Grant number: 11/17575-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2011
• End date: October 31, 2012
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Juliana Irani Fratucci de Gobbi
• Grantee: Tamires Ferreira Siqueira
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Aortic Regurgitation (AR) leads to left ventricle dilation and hypertrophy in response to a chronic volume overload. It is still very frequent in developing countries, like Brazil, and is often secondary to rheumatic fever. Usually, chronic AR is generally well tolerated for many years, when with the heart dilated the patient search for treatment. Bidirectional association with depression and cardiovascular disease has been described. Selective serotonin reuptake inhibitors (SSRI) are widely prescribed to treat several affective disorders, especially for cardiovascular patients since they decrease arrhythmia probability. These SSRIs improve cardiac function in rats submitted to stress protocols. In addition, there is an important central serotonergic pathway, located in the midbrain and pons, which decreases sodium and water intake. A preliminary study in our laboratory showed that following 4 weeks of treatment with one SSRI (paroxetine) in subchronic AR rats there was a decrease in daily sodium intake and an improvement in systolic function. Therefore, in the present project we intend to study the effects of 4 weeks of paroxetine treatment in subchronic AR on a) baroreflex function, and b) possible changes in sodium and potassium excretion.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FRATUCCI DE GOBBI, JULIANA IRANI; MIEKO OMOTO, ANA CAROLINA; SIQUEIRA, TAMIRES FERREIRA; MATSUBARA, LUIZ SHIGUETO; ROSCANI, MELIZA GOI; MATSUBARA, BEATRIZ BOJIKIAN. Antidepressant treatment decreases daily salt intake and prevents heart dysfunction following subchronic aortic regurgitation in rats. Physiology & Behavior, v. 144, p. 124-128, MAY 15 2015. (09/51222-8, 11/17575-0)