Study of post-translational modification on claudins, a family of TJ proteins, on the establishment of giardiasis

• Grant number: 11/14573-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2012
• End date: June 30, 2013
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Renata Rosito Tonelli
• Grantee: Bruno Martorelli Di Genova
• Host Institution: Fundação de Apoio à Universidade Federal de São Paulo (FAP-UNIFESP). São Paulo , SP, Brazil
• Associated research grant: 10/15042-2 - Infection by Giardia lamblia: search for molecules involved in parasita-host interaction, AP.JP

Abstract

The giardiasis, caused by the protozoa Giardia Lamblia, is one of the intestinal disease with the major incidence in the world. The parasite colonizes the small intestine of mamalian and the infection is caracterized by diarrhea. The interaction trophozoite-cell changes both the morfology and the function of the tissue. The tight junctions of the epithelial cells are broken during the infection, leading a hypersecretion of electrolytes. Little is known about the signalization pathways and proteins changed in the giardiasis. This project wants to relacionate the fosforilation profile of TJ proteins, especificly claudins, with the rupture of tight junctions and the establishment of giardiasis.