Cytogenetic studies to detect diagnostics and prognostics markers in bone Sarcoma

• Grant number: 11/22565-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2012
• End date: December 31, 2012
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Marcelo Razera Baruffi
• Grantee: Bruna Paes de Barros
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

The search for identifying factors that may point to the diagnosis, therapeutic response, and survival of patients with bone sarcoma has been incessant. Assuming the tumor aggressiveness, tissue invasiveness, likelihood of recurrence, a propensity to develop metastasis, and response to treatment may be valuable hours in the selection of the therapy. Although dietary and environmental factors contribute to the etiology of cancer, cancer originated from a multistep process involving alterations of genes and clonal selection of variant progeny. These classes of mutations occur in genes that regulate cell proliferation such as oncogenes, tumor suppressor genes, growth factors, signaling pathways, and genes for DNA repair. The knowledge of tumor biology has improved my understanding of the multiple aspects of carcinogenesis. However, although the outlook remains, so far, there are few benefits for the prevention, diagnosis, treatment, and monitoring of patients with bone sarcomas. This research project aims to detect and describe consistent and recurrent chromosomal changes by using classical cytogenetic analysis and their involvement with prognosis in primary and secondary bone sarcomas in an attempt to contribute to the achievement of more effective strategies for improving survival rates and benefit a greater number of patients with bone sarcomas.(AU)