Identification of new molecular targets for the development of therapeutic alternatives for human glioblastomas

• Grant number: 11/23715-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2012
• End date: February 28, 2013
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Ricardo Jose Giordano
• Grantee: Alinne Le Fosse de Souza
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Intracranial neoplasias are one of the main causes of death among the population in general. Glioblastoma is the most frequent form of brain tumor in adults and the patients with this type of tumor live on average two years after the diagnosis. Malignant gliomas exhibit proliferation, angiogenesis and invasion to adjacent areas. The metodology of Phage Display of peptides will be used to scan the surface of human glioblastoma cells, searching new molecular markers that can be transformed in therapeutic alternatives for this disease.