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Imunofluorescence analisys of colagen type I, III, IV and V in experimental pulmonary fibrotic model induced by Bleomicine

Grant number: 12/07040-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2012
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal researcher:Vera Luiza Capelozzi
Grantee:Deborah Bernardo Lopes
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Fibrosing lung diseases (FLD) are a serious problem to health and are ranked high among chronic degenerative diseases due to its morbidity. The factors triggering the development of FLD are not well known. Immunological, genetic and/or viral components may be present. All DPF remodel the lung architecture due to constant activation, proliferation and differentiation of fibroblasts/myofibroblasts, affecting and determining the different structures in this way, qualitative and quantitative functional changes. Certainly epithelial, vascular and matrix contribute to activation of fibroblasts/myofibroblasts with altered expression of their biomechanical properties, modulated by changes in the activity of immunomodulatory receptors that generate or disruption of normal spatial formation of these cells, contributing in the process of fibrosis. Although these cells are widely studied many aspects are still poorly understood.In the present paper we have raised the hypothesis that fibroblasts/myofibroblasts given different mechanisms of pulmonary lesion occur in experimental models of fibrosing diseases induced by bleomycin (BLM, which enables us to establish the remodeling process closer to the human pulmonary fibrosis. The study and comprehension of the mechanisms linked with the increase in collagen fibers, in the cells intervening in their production and in the functional analysis of pulmonary fibrosis mechanisms can contribute to understanding these fibrotic pulmonary diseases' pathogenesis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FELIX, RENATO GONCALVES; CARVALHO BOVOLATO, ANA LIVIA; COTRIM, ONDINA SILVIA; LEAO, PATRICIA DOS SANTOS; BATAH, SABRINA SETEMBRE; GOLIM, MARJORIE DE ASSIS; VELOSA, ANA PAULA; TEODORO, WALCY; MARTINS, VANESSA; CRUZ, FERNANDA FERREIRA; DEFFUNE, ELENICE; FABRO, ALEXANDRE TODOROVIC; CAPELOZZI, VERA LUIZA. Adipose-derived stem cells and adipose-derived stem cell-conditioned medium modulate in situ imbalance between collagen I-and collagen V-mediated IL-17 immune response recovering bleomycin pulmonary fibrosis. HISTOLOGY AND HISTOPATHOLOGY, v. 35, n. 3, p. 289-301, MAR 2020. Web of Science Citations: 0.
MARTINS, VANESSA; TEODORO, WALCY ROSOLIA; VELOSA, ANA PAULA PEREIRA; ANDRADE, PRISCILA; FARHAT, CECILIA; FABRO, ALEXANDRE TODOROVIC; CAPELOZZI, VERA LUIZA. Butylated hydroxytoluene induces type-V collagen and overexpression of remodeling genes/proteins in experimental lung fibrosis. HISTOLOGY AND HISTOPATHOLOGY, v. 33, n. 10, p. 1111-1123, OCT 2018. Web of Science Citations: 1.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.