The effects of polyvinyliden meshes when implanted in rabbits vaginal mucosa

• Grant number: 12/09091-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2012
• End date: June 30, 2014
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Fernando Gonçalves de Almeida
• Grantee: Nikoly Tigani Fares
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Urinary incontinence is a devastating medical problem worldwide. In the United States of America (Euan) more than 17 million people are affected by this disease. The annual cost of treatment of urinary incontinence (UI), in that country, was estimated at approximately $ 26 billion, equivalent to over a thousand dollars per patient per year. The treatment of stress urinary incontinence through the use of a "sling" pubovaginal elevated levels of scientific evidence regarding the rate of healing. However, it has some health problems related to the collection of aponeurosis. In order to reduce these levels began using fabrics made of synthetic materials such as polypropylene (PP). However, the use of such material has presented a relatively high rate of complications. In order to reduce these complications, it has been studied the use of polyvinylidene fluoride (PVDF) mesh for the treatment of stress incontinence since this material has been shown very promising in the treatment of hernias. Thus, this study aims to evaluate the effects of PVDF mesh in the vaginal area in rabbits. Will be measured voltage levels, inflammation, and fibrosis resulting from the implant of this new material.(AU)