Relation of regional severity of ventilation-associated lung injury with the 18F-fluorodeoxyglucose tracer lung kinetic parameters

• Grant number: 12/18136-3
• Support Opportunities: Scholarships abroad - Research
• Start date: January 01, 2013
• End date: December 31, 2013
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Luiz Fernando dos Reis Falcão
• Grantee: Luiz Fernando dos Reis Falcão
• Host Investigator: Marcos Francisco Vidal Melo
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Institution abroad: Massachusetts General Hospital, United States

Abstract

Acute respiratory distress syndrome (ARDS) is a disease of high mortality rate and economic impact. Mechanical ventilation is usually used in patients with this disease, aggravating pre-existing lung damage (ventilation-induced lung injury - VILI). Inflammation is a key attribute to disease progression and resolution. However, the relationship between regional lung inflammation magnitude and shunt severity, ventilation-perfusion ratio, and alveolar damage is not known. Positron emission tomography with 18F-FDG can be used to evaluate the metabolic activity of inflammatory cells in the lung; this procedure is of great clinical relevance since it is considered a noninvasive assessment method. The purpose of this research is to establish a relationship between the kinetic parameters of 18F-FDG and regional severity lung dysfunction and alveolar damage. This study initiates the cooperation between the research group from the Department of Anesthesiology, Pain and Critical Care Medicine - Federal University of Sao Paulo and the Department of Anesthesia, Critical Care and Pain Medicine of Massachusetts General Hospital - Harvard Medical School. (AU)