INTRACYTOPLASMATIC SPERM INJECTION (ICSI) VERSUS INTRACYTOPLASMATIC MORPHOLOGICALLY SELECTED SPERM INJECTION (IMSI) FOR ASSISTED REPRODUCTION OUTCOMES: SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

• Grant number: 12/20881-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: February 01, 2013
• End date: October 31, 2013
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Wellington de Paula Martins
• Grantee: Danielle Medeiros Teixeira
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

INTRODUCTION: DESPITE THE SCIENTIFIC ADVANCES IN ASSISTED REPRODUCTION TECHNIQUES (ART), BOTH CLINICAL PREGNANCY AND LIVE BIRTH RATES REMAIN LOW. IN THE PAST DECADE, A NEW TECHNIQUE TO SELECT SPERMATOZOON UNDER HIGH MAGNIFICATION MICROSCOPY (OVER 6000x) WAS DESCRIBED. WITH THIS NEW METHOD, SUBCELLULAR ORGANELLE MALFORMATIONS CAN BE IDENTIFIED. USING THESES GAMETES FOR INTRACYTOPLASMIC INJECTION MIGHT IMPROVE ART OUTCOMES.OBJECTIVES: TO COMPARE INTRACYTOPLASMATIC SPERM INJECTION (ICSI) AND INTRACYTOPLASMATIC MORPHOLIGICALLY SELECTED SPERM INJECTION (IMSI) MAJOR OUTCOMES: LIVE BIRTHS, CLINICAL PREGNANCY AND MISCARRIAGE.METHODS: RANDOMIZED CONTROLLED TRIALS FOUND IN THE MAIN ELECTRONIC DATABASES WILL BE INCLUDED. DATA WILL BE COMBINED FOR A METANALYSIS. NO DATE OR LANGUAGE RESTRICITION WILL BE IMPOSED.