Correlation of histologic features of atherosclerotic plaques with coronary risk factors and the presence of biomarkers

• Grant number: 12/11871-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2013
• End date: March 31, 2015
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Alexandre da Costa Pereira
• Grantee: Bianca Kiers
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Atherosclerosis is considered the primary cause of cardiovascular diseases which are mostly resulting from plaque rupture and thrombosis. Histological patterns of atherosclerotic plaques may be correlated with the presence of risk factors and knowledge of this connection will verify individuals prone to developing the disease. Whereas the arterial wall is an important site of nitro-oxidative modification of proteins in diseases such as atherosclerosis, nitrated proteins are quantified. This will allow for a more systemic approach in the detection of patients at risk, because nitrated proteins serve as biomarkers. Approximately 1000 atherosclerotic plaques will be organized in a database, classified according to the American Heart Association in relation to histologic and correlated with the presence of risk factors. The identification and quantification of protein nitrated be carried out using the technique of immunohistochemistry with anti-nitrotyrosine. The achievement of this identification of a large number of atherosclerotic plaques in each of the different degrees of vulnerability allow the development of new diagnostic techniques. Data will be entered and checked using the application's resources IMPS 4.1, and subsequently implemented in the SPSS program for descriptive statistical analysis of data obtained.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VANCHIN, BYAMBASUREN; OFFRINGA, EMMA; FRIEDRICH, JULIAN; BRINKER, MARJA G. L.; KIERS, BIANCA; PEREIRA, ALEXANDRE C.; HARMSEN, MARTIN C.; MOONEN, JAN-RENIER A. J.; KRENNING, GUIDO. MicroRNA-374b induces endothelial-to-mesenchymal transition and early lesion formation through the inhibition of MAPK7 signaling. JOURNAL OF PATHOLOGY, v. 247, n. 4, p. 456-470, APR 2019. (12/11871-0)

VANCHIN, BYAMBASUREN; SOL, MARLOES; GJALTEMA, RUTGER A. F.; BRINKER, MARJA; KIERS, BIANCA; PEREIRA, ALEXANDRE C.; HARMSEN, MARTIN C.; MOONEN, JAN-RENIER A. J.; KRENNING, GUIDO. Reciprocal regulation of endothelial-mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease. SCIENTIFIC REPORTS, v. 11, n. 1, SEP 7 2021. (12/11871-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

KIERS, Bianca. Characterization of atherosclerotic plaques with regard to morphology, inflammation and nitrated proteins. 2016. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.