Search for natural compounds with potential use against resistant bacteria

• Grant number: 12/22636-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2013
• End date: February 29, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wilson Roberto Cunha
• Grantee: Marcos Gomide Tozatti
• Host Institution: Reitoria. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

The aim of this project is: the obtainment of some molecules of interest (ursolic acid, oleanolic acid, rosmarinic acid , usnic acid and difractaic acid) present in natural sources, and the evaluation of these compounds against resistant bacteria. The aim is also to prepare some derivatives for optimization of results obtained in these bioassays. The compounds that present promising will be evaluated for their cytotoxicity. The promising compounds will also be incorporated into nanoparticles and evaluated their release profile. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TOZATTI, MARCOS G.; FERREIRA, DANIELE S.; BOCALON FLAUZINO, LUZIO G.; MORAES, THAIS DA SILVA; MARTINS, CARLOS H. G.; GROPPO, MILTON; ANDRADE E SILVA, MARCIO L.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; CUNHA, WILSON R.. Activity of the Lichen Usnea steineri and its Major Metabolites against Gram-positive, Multidrug-resistant Bacteria. NATURAL PRODUCT COMMUNICATIONS, v. 11, n. 4, p. 493-496, APR 2016. (12/16182-8, 12/22636-1)