Innate immunity in blood and mammary secretion of Holstein cows in the peripartum period

• Grant number: 12/24475-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2013
• End date: April 30, 2014
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Viviani Gomes
• Grantee: Cynthia Pereira da Costa e Silva
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The peripartum is a critical period in which the immunological and physiological adaptations occurred may be responsible for susceptibility to mammary infections, during colostrogenesis. Thus, the study of innate immunity and its response to bacterial pathogens are crucial for understanding, diagnosis and prophylactic measures for bovine mastitis. Therefore, this work has the objective of evaluating the innate immunity in blood and mammary secretion of Holstein cows in the peripartum period and its response to natural exposure to bacterial pathogens during colostrogenesis. For this, blood samples will be evaluated and mammary secretion of ten cows, multiparous and pregnant. Cows will be evaluated weekly during the three weeks preceding and following the predicted birth. The evaluation of the innate immune response and detection of the inflammatory process will be carried out through clinical examination of the mammary apparatus, bacteriological examination of colostrum and immunological tests, such as measurement of proinflammatory cytokines, and immunophenotyping functional assessment of polymorphonuclear leukocytes CH138+. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Cynthia Pereira da Costa e. Innate immunity in blood and mammary secretion of Holstein cows in the peripartum period. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.