Development of biosensoric devices based on microchannel technology for application in food analysis, clinical diagnosis and enzymology.

• Grant number: 13/00972-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2013
• End date: May 31, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Lucio Angnes
• Grantee: Rastislav Monosik
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This post-doc project will focus on the development of micro-enzymatic reactors dedicated to biotransformation of different analytes, important for analysis in medical area and in food industry. During the post-doc studies, the following aspects will be emphasized: First, the construction of micro reactors will be done preferentially using PMMA, due this material is transparent, easy to work and in the working group was developed methodology for sealing parts using heat and pressure; Second, chemical modification of this material is relatively easy and the literature presents some studies involving this material; Third, the group where this study will be done, have good expertise in the development of miniaturized electrochemical sensors and the possibility of built these sensors connected to the microchannels can lead to interesting devices; Fourth, in the research group the modification of electrodes is a strong research line and the utilization of modified electrodes is another interesting possibility. The final goal of this project is obtain relatively small devices that can be easily reproduced and replaced in applications where numerous analyses are necessary.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MONOSIK, RASTISLAV; ANGNES, LUCIO. Utilisation of micro- and nanoscaled materials in microfluidic analytical devices. Microchemical Journal, v. 119, p. 159-168, MAR 2015. (13/00972-2)

MONOSIK, RASTISLAV; DOS SANTOS, VAGNER BEZERRA; ANGNES, LUCIO. A simple paper-strip colorimetric method utilizing dehydrogenase enzymes for analysis of food components. ANALYTICAL METHODS, v. 7, n. 19, p. 8177-8184, 2015. (13/00972-2)