The role of SUMOylation of proteins in cell biology of Giardia lamblia and in the interaction with the host

• Grant number: 13/04272-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: July 01, 2013
• End date: July 31, 2016
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Renata Rosito Tonelli
• Grantee: Bruno Martorelli Di Genova
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 10/15042-2 - Infection by Giardia lamblia: search for molecules involved in parasita-host interaction, AP.JP

Abstract

SUMOylation is a post-translational modification of proteins characterized by the addition of an ubiquitin-like protein in lysine residues of the substrate. In this study, SUMOylation pathway in Giardia lamblia, a protozoan parasite which colonizes mammals small intestines, will be studied. Cellular biology aspects of the parasite, of its life cycle and its interaction with its host will be analyzed with the participation of SUMO in these processes. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DI GENOVA, BRUNO M.; TONELLI, RENATA R.. Infection Strategies of Intestinal Parasite Pathogens and Host Cell Responses. FRONTIERS IN MICROBIOLOGY, v. 7, MAR 3 2016. (10/15042-2, 13/04272-5)

DI GENOVA, BRUNO M.; DA SILVA, RICHARD C.; DA CUNHA, JULIA P. C.; GARGANTINI, PABLO R.; MORTARA, RENATO A.; TONELLI, RENATA R.. Protein SUMOylation is Involved in Cell-cycle Progression and Cell Morphology in Giardia lamblia. Journal of Eukaryotic Microbiology, v. 64, n. 4, p. 491-503, JUL-AUG 2017. (10/15042-2, 13/04272-5)