Study of resorbable polymers: the effect of degradation and erosion on dye release

• Grant number: 13/12174-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: September 02, 2013
• End date: January 01, 2014
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Osvaldo de Freitas
• Grantee: Renê Oliveira Do Couto
• Supervisor: Joachim B. Kohn
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Rutgers The State University of New Jersey, New Brunswick, United States
• Associated to the scholarship: 12/06167-1 - Development of mucoadhesive films for anesthetic release on the buccal cavity, BP.DR

Abstract

During the recent years, increasing efforts have been devoted to the development of biodegradable polymers for pharmaceutical application. In this pursuit, Prof. Joachim Kohn and co-workers at the New Jersey Center for Biomaterials at Rutgers, The State University of New Jersey, have developed a proprietary combinatorial polymer library of biocompatible, biodegradable tyrosine-derived copolymers comprising polycarbonates, polyarylates, and polyethers. These polymers are able to degrade with concomitant erosion and drug release and, therefore, represent a new and promising drug delivery platform. Here we propose the systematic investigation of the mechanisms and kinetics of degradation and erosion of a resorbable tyrosine-derived polycarbonate terpolymer (E2005(1k)) and its impact on the dye release from compression molded thin films. Polymeric films will be characterized in terms of several physical and physicochemical properties e.g. water uptake, chemical kinetics of degradation reactions of the polymer backbone, physical erosion, mechanical properties and kinetics of dye release. The development of this proposal may validate a new bioerodible drug delivery platform for controlled drug release. Furthermore, the internship at Rutgers University may bring substantial contribution to the scientific and personal formation of the student and initiates a fruitful collaboration with Prof. Kohn's group. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DO COUTO, RENE OLIVEIRA; CUBAYACHI, CAMILA; DUARTE, MAIRA PERES FERREIRA; LOPEZ, RENATA FONSECA VIANNA; PEDRAZZI, VINICIUS; GAITANI, CRISTIANE MASETTO DE; FREITAS, OSVALDO DE. Towards the advance of a novel iontophoretic patch for needle-free buccal anesthesia. Materials Science & Engineering C-Materials for Biological Applications, v. 122, MAR 2021. (12/05644-0, 14/22451-7, 13/12174-3)

SILVA FAVACHO, HUGO ALEXANDRE; DO COUTO, RENE OLIVEIRA; FERREIRA DUARTE, MAIRA PERES; GAROFO PEIXOTO, MARIA PAULA; VIANNA LOPEZ, RENATA FONSECA; PEDRAZZI, VINICIUS; DE GAITANI, CRISTIANE MASETTO; DE FREITAS, OSVALDO. Synergy between surfactants and mucoadhesive polymers enhances the transbuccal permeation of local anesthetics from freeze-dried tablets. Materials Science & Engineering C-Materials for Biological Applications, v. 108, MAR 2020. (12/05644-0, 12/06167-1, 12/07251-6, 13/12174-3, 14/22451-7)

DO COUTO, RENE OLIVEIRA; CUBAYACHI, CAMILA; CALEFI, PAULO LINARES; VIANNA LOPEZ, RENATA FONSECA; PEDRAZZI, VINICIUS; DE GAITANI, CRISTIANE MASETTO; DE FREITAS, OSVALDO. Combining amino amide salts in mucoadhesive films enhances needle-free buccal anesthesia in adults. JOURNAL OF CONTROLLED RELEASE, v. 266, p. 205-215, NOV 28 2017. (12/07251-6, 12/05644-0, 13/12174-3, 14/22451-7, 12/06167-1)

CUBAYACHI, CAMILA; DO COUTO, RENE OLIVEIRA; DE GAITANI, CRISTIANE MASETTO; PEDRAZZI, VINICIUS; DE FREITAS, OSVALDO; VIANNA LOPEZ, RENATA FONSECA. Needle-free buccal anesthesia using iontophoresis and amino amide salts combined in a mucoadhesive formulation. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 136, p. 1193-1201, DEC 1 2015. (13/12174-3, 12/05644-0)

DO COUTO, RENO O.; SOMMERFELD, SVEN D.; DUBE, KOUSTUBH; DE FREITAS, OSVALDO; KOHN, JOACHIM. PRELIMINARILY DEVELOPMENT OF A MOISTURE-ACTIVATED BIORESORBABLE POLYMERIC PLATFORM FOR DRUG DELIVERY. Química Nova, v. 38, n. 7, p. 902-909, AUG 2015. (12/06167-1, 12/07251-6, 13/12174-3)