Nanostructured antimicrobial coatings containing chitosan produced by self-assembly technique (layer-by-layer) for textile substrates

• Grant number: 13/05135-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2013
• End date: February 28, 2017
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Marisa Masumi Beppu
• Grantee: Thiago Bezerra Taketa
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The research on bioactive materials, especially coatings, enables the production of resistant, nontoxic, biodegradable, and suitable antimicrobial surfaces for contact with food or humans. This project will combine the effect of different types of chitosan in the manufacture of nanostructured films for antimicrobial coatings on textile substrates and glass slides. The optimization of the properties of the coatings from changes in the structure of chitosan will be emphasized, for example, with controlled variation of the average degree of acetylation (DA), pattern of acetylation (PA), and average degree of polymerization (DP), using different deposition techniques based on self-assembly methods (layer-by-layer, LbL) : dip and spray coating. To reach the desired antimicrobial activity, this optimization process include extensive characterization of chitosans and coatings, with a variety of experimental techniques, especially surface analysis. The results of this characterization will be correlated with antimicrobial activity inferred from specific tests with microorganisms of great importance to biomedical and textile applications. To achieve large scale and enable the commercial application of the coatings, the deposition of chitosan with the spray LbL technique will be investigated. In the midst of technological innovation, we expect to incorporate frontier research in which interactions at the molecular level and properties of surfaces are studied, generating scientific contributions of high impact. (AU)

Scientific publications

(13)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROCHA NETO, J. B. M.; GOMES NETO, R. J.; BATAGLIOLI, R. A.; TAKETA, T. B.; PIMENTEL, S. B.; BARATTI, M. O.; COSTA, C. A. R.; CARVALHO, H. F.; BEPPU, M. M.. Engineering the surface of prostate tumor cells and hyaluronan/chitosan multilayer films to modulate cell-substrate adhesion properties. International Journal of Biological Macromolecules, v. 158, p. 197-207, SEP 1 2020. (16/19976-6, 16/10193-9, 13/05135-1)

VAZ, JULIANA M.; TAKETA, THIAGO B.; HERNANDEZ-MONTELONGO, JACOBO; FIUZA, LARISSA M. C. G.; RODRIGUES, CRISTIANO; BEPPU, MARISA M.; VIEIRA, RODRIGO S.. Antibacterial noncytotoxic chitosan coatings on polytetrafluoroethylene films by plasma grafting for medical device applications. Journal of Coatings Technology and Research, JAN 2022. (13/05135-1)

BATAGLIOLI, R. A.; TAKETA, T. B.; ROCHA NETO, J. B. M.; LOPES, L. M.; COSTA, C. A. R.; BEPPU, M. M.. Analysis of pH and salt concentration on structural and model-drug delivery properties of polysaccharide-based multilayered films. Thin Solid Films, v. 685, p. 312-320, SEP 1 2019. (13/05135-1, 16/19976-6, 16/10193-9)

LIMA, LONETA LAURO; TAKETA, THIAGO BEZERRA; BEPPU, MARISA MASUMI; DE OLIVEIRA SOUSA, ILZA MARIA; FOGLIO, MARY ANN; MORAES, ANGELA MARIA. Coated electrospun bioactive wound dressings: Mechanical properties and ability to control lesion microenvironment. Materials Science & Engineering C-Materials for Biological Applications, v. 100, p. 493-504, JUL 2019. (15/08338-6, 13/05135-1)

TAKETA, THIAGO B.; ROCHA NETO, JOAO BATISTA M.; DOS SANTOS, DANILO M.; FIAMINGO, ANDERSON; BEPPU, MARISA M.; CAMPANA-FILHO, SERGIO PAULO; COHEN, ROBERT E.; RUBNER, MICHAEL F.. Tracking Sulfonated Polystyrene Diffusion in a Chitosan/Carboxymethyl Cellulose Layer-by-Layer Film: Exploring the Internal Architecture of Nanocoatings. Langmuir, v. 36, n. 18, p. 4985-4994, MAY 12 2020. (13/05135-1)

VAZ, JULIANA M.; TAKETA, THIAGO B.; HERNANDEZ-MONTELONGO, JACOBO; CHEVALLIER, PASCALE; COTTA, MONICA A.; MANTOVANI, DIEGO; BEPPU, MARISA M.. Antibacterial properties of chitosan-based coatings are affected by spacer-length and molecular weight. Applied Surface Science, v. 445, p. 478-487, JUL 1 2018. (13/14888-3, 10/51748-7, 13/10957-0, 13/05135-1)

ROCHA NETO, J. B. M.; TAKETA, T. B.; BATAGLIOLI, R. A.; PIMENTEL, S. B.; SANTOS, D. M.; FIAMINGO, A.; COSTA, C. A. R.; CAMPANA-FILHO, S. P.; CARVALHO, H. F.; BEPPU, M. M.. Tailored chitosan/hyaluronan coatings for tumor cell adhesion: Effects of topography, charge density and surface composition. Applied Surface Science, v. 486, p. 508-518, AUG 30 2019. (16/19976-6, 13/05135-1, 16/10193-9)

CUNHA, BRUNO S.; BATAGLIOLI, ROGERIO A.; TAKETA, THIAGO B.; LOPES, LAISE M.; BEPPU, MARISA M.. Ionic liquid functionalization of chitosan beads for improving thermal stability and copper ions uptake from aqueous solution. JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING, v. 7, n. 3, JUN 2019. (16/10193-9, 13/05135-1)

MAHL, CYNTHIA R. A.; TAKETA, THIAGO B.; BATAGLIOLI, ROGERIO A.; DE ARRUDA, EDUARDO JOSE; BEPPU, MARISA M.. Chitosan Functionalization with Amino Acids Yields to Higher Copper Ions Adsorption Capacity. JOURNAL OF POLYMERS AND THE ENVIRONMENT, v. 26, n. 12, p. 4338-4349, DEC 2018. (13/05135-1, 16/10193-9)

TAKETA, THIAGO B.; DOS SANTOS, DANILO M.; FIAMINGO, ANDERSON; VAZ, JULIANA M.; BEPPU, MARISA M.; CAMPANA-FILHO, SERGIO P.; COHEN, ROBERT E.; RUBNER, MICHAEL F.. Investigation of the Internal Chemical Composition of Chitosan-Based LbL Films by Depth-Profiling X-ray Photoelectron Spectroscopy (XPS) Analysis. Langmuir, v. 34, n. 4, p. 1429-1440, JAN 30 2018. (13/05135-1)

DEMIR, ALI GOEKHAN; TAKETA, THIAGO B.; TOLOUEI, RANNA; FURLAN, VALENTINA; PATERNOSTER, CARLO; BEPPU, MARISA M.; MANTOVANI, DIEGO; PREVITALI, BARBARA. Laser surface structuring affects polymer deposition, coating homogeneity, and degradation rate of Mg alloys. Materials Letters, v. 160, p. 359-362, DEC 1 2015. (13/05135-1)

SPERA, MARCELLE B. M.; TAKETA, THIAGO B.; BEPPU, MARISA M.. Roughness dynamic in surface growth: Layer-by-layer thin films of carboxymethyl cellulose/chitosan for biomedical applications. BIOINTERPHASES, v. 12, n. 4, DEC 2017. (13/05135-1)

CARNEIRO, RAFAEL T. A.; TAKETA, THIAGO B.; GOMES NETO, REGINALDO J.; OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; DE MORAES, MARIANA A.; DA SILVA, CAMILA M. G.; BEPPU, MARISA M.; FRACETO, LEONARDO F.. Removal of glyphosate herbicide from water using biopolymer membranes. Journal of Environmental Management, v. 151, p. 353-360, MAR 15 2015. (13/05135-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TAKETA, Thiago Bezerra. Nanostructured antimicrobial coatings containing chitosan produced by self-assembly technique (layer-by-layer) for textile substrates. 0000. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Química Campinas, SP.