Nanoskin: use to replace volume in the anophthalmic cavity

• Grant number: 13/04996-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2013
• End date: August 31, 2014
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Silvana Artioli Schellini
• Grantee: Maria Julia de Barros Orsolini
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Nanoskin is a cellulose produced by a Gram-negative bacterium based on sugar cane substrate. Purpose: to evaluate the biocompatibility of Nanoskin spheres to recover volume in the anophthalmic cavities. Methods: twenty-four rabbits that will have the right eye eviscerated (G1) or enucleated (G2), with replacement of lost volume using 10 mm spheres of Nanoskin. The control group (G3) will be composed by animals from preliminary study in which were implanted porous polyethylene spheres (Schellini et al., 2005), considered the gold standard in this field. The animals will be euthanized at 7, 90 and 180 days after the initial surgery. The biocompatibility of the spheres will be studied by daily clinical examination, histological evaluation and morphometric analysis of the tissue reaction. Quantitative data will be submitted to statistical analysis. (AU)