Involvement of Kiss1 neurons in the neural pathway through which the circadian system regulates the ovulatory cycle

• Grant number: 13/00801-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2013
• End date: January 31, 2015
• Field of knowledge: Biological Sciences - Morphology
• Principal Investigator: Renata Frazão
• Grantee: Regina Silva Paradela
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

In the neuroendocrine control of the ovulatory cycle is very well known that the LH surge is an event that occurs at specific time of the day. The preovulatory LH surge is initiated on the day of proestrus when estrogen levels are high. Several evidences implicate that environmental clues in association to estrogen levels are responsible for the synchronization of the ovulatory cycle. It has been previous suggested that Kiss1 neurons from AVPV has intricate connections with the SCN and would be consider the intermediate pathway through which SCN inputs modulates GnRH activity. SCN neurotransmitters are known to induce changes in LH secretion. Vasopressin receptors expression increases in AVPV due to high estrogen levels, but the neurochemical identity of such neurons are not known. Due to the importance of Kiss1 expressing neurons on reproduction the present investigation will employ neuroanatomical tools to test the hypothesis that estrogen levels are able to modulate the colocalization of vasopressin receptors and Kiss1 neurons.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FRAZAO, RENATA; LEMKO, HEATHER M. DUNGAN; DA SILVA, REGINA P.; RATRA, DHIRENDER V.; LEE, CHARLOTTE E.; WILLIAMS, KEVIN W.; ZIGMAN, JEFFREY M.; ELIAS, CAROL F.. Estradiol modulates Kiss1 neuronal response to ghrelin. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 306, n. 6, p. E606-E614, MAR 2014. (12/12554-8, 13/00801-3, 12/12202-4)

BOHLEN, TABATA M.; DE PAULA, DANIELLA G.; TEIXEIRA, PRYSCILA D. S.; MANSANO, NAIRA DA SILVA; ALVES, GUILHERME ANDRADE; DONATO JR, JOSE; FRAZAO, RENATA. Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss. CYTOKINE, v. 158, p. 9-pg., 2022-08-17. (15/14588-5, 19/21707-1, 20/01318-8, 13/00801-3, 16/03082-6, 17/22189-9)

DA SILVA, REGINA P.; ZAMPIERI, THAIS T.; PEDROSO, JOAO A. B.; NAGAISHI, VANESSA S.; RAMOS-LOBO, ANGELA M.; FURIGO, ISADORA C.; CAMARA, NIELS O.; FRAZAO, RENATA; DONATO, JR., JOSE. Leptin Resistance Is Not the Primary Cause of Weight Gain Associated With Reduced Sex Hormone Levels in Female Mice. Endocrinology, v. 155, n. 11, p. 4226-4236, NOV 2014. (13/00801-3, 10/18086-0, 12/12202-4, 13/16374-7, 12/02270-2, 12/15517-6, 13/21722-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PARADELA, Regina Silva. Involvement of Kiss1 neurons in the neural pathway through which the circadian system regulates ovulatory cycle.. 2015. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.