Involvement of purinergic receptors in the expression, reconsolidation and extinction processes of contextual conditioned memory in mice.

• Grant number: 13/08674-0
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2013
• Effective date (End): October 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Leonardo Resstel Barbosa Moraes
• Grantee: Luana Barreto Domingos
• Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 12/17626-7 - Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders, AP.TEM

Abstract

Purinergic receptors activation (P2R) by adenosine 5'-triphosphate (ATP) in the central nervous system (CNS) appears to be involved in anxiety responses. Studies indicate that activation of P2R modulates the synthesis of nitric oxide (NO) via activation of neuronal isoform of NO synthase (nNOS). There is evidence that administration of nNOS inhibitor decreases the expression and facilitates extinction of conditioned fear memory associated to context (MCC). Thus, the pharmacological blockade of receptors P2R could cause similar effects. However, there are no studies investigating the effects induced by administration of antagonists P2R, particularly P2X receptor, in animals subjected to MCC.Thus, the hypothesis of project is that the P2X receptors antagonism will promote a change in the processes of memory associated with the MCC. To test this hypothesis, we will carry out pharmacological manipulation P2XR receptors and evaluate the processes of expression, reconsolidation and extinction of contextual aversive memory in the MCC.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOMINGOS, L. B.; HOT, S. C.; TERZIAN, A. L. B.; RESSTEL, L. B. M. P2X7 purinergic receptors participate in the expression and extinction processes of contextual fear conditioning memory in mice. Neuropharmacology, v. 128, p. 474-481, JAN 2018. Web of Science Citations: 4.