Cell differentiation in the gastric mucosa of rats: role of dietary patterns during postnatal development

• Grant number: 13/18459-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2013
• End date: May 31, 2015
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Patrícia Gama
• Grantee: Larissa Yukari Massarenti Hosoya
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The development of the gastrointestinal tract depends on proper suckling-weaning transition. In the gastric mucosa, hormones and milk-born peptides regulate cell proliferation, differentiation and death. Our hypothesis is that suckling is one of the main regulatory agents during development, and so, changes in dietary pattern or conditions can alter the rate of cell differentiation and consequently the maturation of gastric mucosa. In order to test this idea, this proposal aims to evaluate the role of dietary patterns on mucous neck cell population (a differentiation marker) and mucin 6 production (glycoprotein secreted by these cells). During postnatal development, rats will be submitted to either maternal separation or early weaning and the stomach will be collected at 18 and 30 days to extract protein and tissue for histochemistry. Results will be put together according to experiments and statistically analyze.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OGIAS, DANIELA; RATTES, ISADORA C.; HOSOYA, LARISSA Y. M.; ZULIAN, JULIANA G.; YAN, CHAO YUN IRENE; GAMA, PATRICIA. Neonatal- maternal separation primes zymogenic cells in the rat gastric mucosa through glucocorticoid receptor activity. SCIENTIFIC REPORTS, v. 8, JUN 29 2018. (12/10948-9, 11/17415-3, 14/21449-9, 10/03076-0, 13/18459-0)

ZULIAN, JULIANA GUIMARAES; MASSARENTI HOSOYA, LARISSA YUKARI; FIGUEIREDO, PRISCILA MOREIRA; OGIAS, DANIELA; OSAKI, LUCIANA HARUMI; GAMA, PATRICIA. Corticosterone activity during early weaning reprograms molecular markers in rat gastric secretory cells. SCIENTIFIC REPORTS, v. 7, MAR 31 2017. (13/18459-0, 11/17415-3, 14/21449-9, 10/03076-0)