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Identification of small regulatory RNAs (sRNAs) in Yersinia pestis and Yersinia pseudotuberculosis and correlation with the virulence differences between this two species

Grant number: 13/11325-8
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date: December 01, 2013
End date: May 10, 2017
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Juliana Pfrimer Falcão
Grantee:Roberto Antonio de Souza
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Despite of the fact that Yersinia pestis and Yersinia pseudotuberculosis are genetically very similar, these micro-organisms have significant differences in their pathogenicity. While Y. pestis causes a severe and life-threatening systemic infection know as plague, Y. pseudotuberculosis usually causes a self-limited gastroenteritis. Despite the existence of species-specific virulence factors, they can not fully explain the observed differences in the exacerbated virulence of Y. pestis compared to Y. pseudotuberculosis. Thus, differences in the mechanisms of post-transcriptional regulation between Y. pestis and Y. pseudotuberculosis may be related to the distinct biology of these two pathogens. The recent development of the RNA sequencing methodology (RNA-seq) has contributed substantially for the understanding of the post-transcriptions regulation mechanisms in some micro-organisms and, in this way, the RNA-seq methodology can be used as a valuable tool for the characterization of different mechanisms of post-transcriptional regulation between Y. pestis and Y. pseudotuberculosis. The main objective of this project is to identify by RNA-seq the small regulatory RNAs (sRNAs) encoded by the plasmids and chromosome of Y. pestis and Y. pseudotuberculosis and correlate them with the differences found between these two pathogenic species. The results should outline in more details the qualitative and quantitative characteristics that may be related to the striking difference in the virulence found between these species.

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