Role of P2Y1 receptors within the C1 neurons controlling breathing and blood pressure

• Grant number: 14/04866-5
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: June 02, 2014
• End date: December 01, 2014
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Thiago dos Santos Moreira
• Grantee: Bárbara Falquetto
• Supervisor: Daniel Kent Mulkey
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of Connecticut (UCONN), United States
• Associated to the scholarship: 12/10337-0 - Neural mechanisms involved in purinergic signaling in the control of central and peripheral chemosensitivity, BP.DR

Abstract

Breathing is an essential homeostatic neural process, regulating levels of O2 and CO2 in blood and tissues, which are crucial for life. It is well known that central and peripheral chemoreceptors sense changes in these gases and communicate this information to cardiorespiratory centers to regulate breathing and sympathetic activity outflow to ensure adequate ventilation-perfusion matching in tissues (Feldman et al. 2003). Disruption of chemoreceptor drive has been associated with a number of cardiorespiratory problems including sleep apnea (Dempsey et al., 2010), sudden infant death syndrome (SIDS) (Kinney et al., 2009) and hypertension (Zoccal et al., 2007; Dempsey et al., 2010). However, despite concerted investigation the cellular and molecular basis for central chemoreception has yet to be fully elucidated, and the neural basis for integration of central and peripheral chemosensory inputs within the medulla remains unresolved. The proposed research will try to identify a crucial role of purinergic signaling in peripheral chemoreception, and in doing so offers new potential therapeutic avenues for the treatment of cardiorespiratory control disorders. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

JAMES, S. D.; HAWKINS, V. E.; FALQUETTO, B.; RUSKIN, D. N.; MASINO, S. A.; MOREIRA, T. S.; OLSEN, M. L.; MULKEY, D. K.. Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus. ENEURO, v. 5, n. 6, NOV-DEC 2018. (14/04866-5, 15/23376-1, 16/22069-0)

MOREIRA, THIAGO S.; WENKER, IAN C.; SOBRINHO, CLEYTON R.; BARNA, BARBARA F.; TAKAKURA, ANA C.; MULKEY, DANIEL K.. Independent purinergic mechanisms of central and peripheral chemoreception in the rostral ventrolateral medulla. JOURNAL OF PHYSIOLOGY-LONDON, v. 593, n. 5, p. 1067-1074, MAR 1 2015. (11/13462-7, 10/09776-3, 13/10573-8, 12/10337-0, 09/54888-7, 13/02350-9, 14/04866-5)