Role of peptides in coagulation and platelet aggregation

• Grant number: 14/04178-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2014
• End date: February 28, 2015
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Maria Luiza Vilela Oliva
• Grantee: Diogo Ferri Marques
• Host Institution: Instituto Nacional de Farmacologia (INFAR). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 09/53766-5 - Proteins from plant source with selectivity for inhibition of mammalian enzymes and their role as an anti-inflammatory, antithrombotic, anti-diabetic and anti-tumor agent, AP.TEM

Abstract

Considering the risk-benefit factor of the anticoagulants currently used, and especially the large number of patients requiring the use of these drugs, this project aims to isolate and characterize the anticoagulant and antiplatelet aggregation effects of peptides from Passiflora edulis and other fruits. Our proposal is to alert anticoagulated patients about the risks of consuming a particular fruit. Particularly, this project will investigate the effect of the compounds in the global blood coagulation parameters and platelet aggregation comparing with other previously isolated in our group.