Evaluation of the risk benefit of the use of Omeprazole: a systematic review

• Grant number: 14/03468-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2014
• End date: June 30, 2015
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Patricia de Carvalho Mastroianni
• Grantee: Stephania Furlanetto Mieli
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Introduction: proton pump inhibitors such as omeprazole, are widely administered and mostly effective and safer, but studies reveal that there are adverse events related to chronic use of this drug which possibly compromise the patient's safety. Objective: this study aims to identify the original studies evaluating the use of omeprazole to know the clinical outcomes (identified adverse events and treatment effectiveness). Methods: a systematic review will be conducted in PUBMED, SCOPUS, PAHO, LILACS, SCIELO, EMBASE and EBSCO databases with studies published until May 2014. The search strategy is based on the model The PRISMA Statement by the use of scientific descriptors and manual search to identify the original published studies that evaluated the efficacy and adverse events in the use of omeprazole. The following aspects will be evaluated: time of treatment, indication, adverse events, study design and after the floating reading of pre-selected studies will be identified and included another variables of interest. Method of analysis of the results. The adverse events and the effectiveness of the use of omeprezole based on the variables of interest analyzed. It's intended to know the risk factors and protection for the use of omeprazole, considering the use indication, non indicated use in the instructions (off-label) and time of treatment. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DAGLI-HERNANDEZ, CAROLINA; LUCCHETTA, ROSA CAMILA; DE NADAI, TALES RUBENS; FERNANDEZ GALDUROZ, JOSE CARLOS; MASTROIANNI, PATRICIA DE CARVALHO. Self-perception of knowledge and adherence reflecting the effectiveness of antiretroviral therapy. PATIENT PREFERENCE AND ADHERENCE, v. 10, p. 1787-1793, 2016. (14/03468-6)

VARALLO, FABIANA ROSSI; DE NADAI, TALES RUBENS; ALVES DE OLIVEIRA, ALICE ROSA; MASTROIANNI, PATRICIA DE CARVALHO. Potential Adverse Drug Events and Nephrotoxicity Related to Prophylaxis With Omeprazole for Digestive Disorders: A Prospective Cohort Study. CLINICAL THERAPEUTICS, v. 40, n. 6, p. 973-982, JUN 2018. (13/12681-2, 14/03468-6)

FORGERINI, MARCELA; MIELI, STEPHANIA; MASTROIANNI, PATRICIA DE CARVALHO. Safety assessment of omeprazole use: a review. São Paulo Medical Journal, v. 136, n. 6, p. 557-570, NOV-DEC 2018. (14/03468-6, 13/12681-2)