Heterorresistance to fluconazole in the agents of cryptococcosis
| Grant number: | 14/16459-5 |
| Support type: | Scholarships abroad - Research Internship - Doctorate |
| Effective date (Start): | September 10, 2014 |
| Effective date (End): | December 09, 2014 |
| Field of knowledge: | Biological Sciences - Microbiology |
| Principal Investigator: | Marcia de Souza Carvalho Melhem |
| Grantee: | Dayane Cristina da Silva Santos |
| Supervisor abroad: | Salman Tahir Qureshi |
| Home Institution: | Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil |
| Local de pesquisa : | McGill University, Canada |
| Associated to the scholarship: | 12/21563-0 - Evaluation of polymorphic isolates of Cryptococcus neoformans and c. gattii tolerant to Amphotericin B in mouse models and alternative, BP.DR |
Abstract Cryptococcosis presents three forms-cutaneous, pulmonary, and meningococcal-and is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Susceptibility to progression cryptococcal infection is regulated by host genetic factors that are poorly understood.The project aims to evaluate cellular and molecular host-response to isolates showing distinct characteristics of polymorphism, tolerance to amphotericin B and high heteroresistance to fluconazole. (AU) | |