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Host-response to Cryptococcus neoformans / c. gattii species complex using polymorphic and antifungal resistant isolates

Grant number: 14/16459-5
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 10, 2014
Effective date (End): December 09, 2014
Field of knowledge:Biological Sciences - Microbiology
Principal researcher:Marcia de Souza Carvalho Melhem
Grantee:Dayane Cristina da Silva Santos
Supervisor abroad: Salman Tahir Qureshi
Home Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Research place: McGill University, Montreal, Canada  
Associated to the scholarship:12/21563-0 - Evaluation of polymorphic isolates of Cryptococcus neoformans and C. gattii tolerant to amphotericin B in mouse models and alternative, BP.DR

Abstract

Cryptococcosis presents three forms-cutaneous, pulmonary, and meningococcal-and is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Susceptibility to progression cryptococcal infection is regulated by host genetic factors that are poorly understood.The project aims to evaluate cellular and molecular host-response to isolates showing distinct characteristics of polymorphism, tolerance to amphotericin B and high heteroresistance to fluconazole. (AU)

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