Initial characterization of the vaccine candidate elicited imune response to Mayaro fever

• Grant number: 14/05600-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2014
• End date: January 31, 2018
• Field of knowledge: Biological Sciences - Microbiology
• Principal Investigator: Maurício Lacerda Nogueira
• Grantee: Mânlio Tasso de Oliveira Mota
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Mayaro virus is an arbovirus belonging to genus Alphavirus, family Togaviridae. It is the etiological agent of Mayaro fever, a dengue-like febrile syndrome. One of the landmarks of this disease is a highly debilitating arthralgia that can persist for months. Another alphavirus, Chikungunya virus is responsible for several outbreaks in Asia, Africa and Oceania, in addition to case reports in Europe. Although restricted to forested areas, it is probable that higher numbers of Mayaro fever cases in the coming years due to the increased number of people inhabiting or making use of these areas. The development of a vaccine is essential to prevent future outbreaks that this virus may cause. Much of the knowledge about MAYV pathology are generalizations based on other alphavirus. An attenuated virus was developed. This virus may be used as a vaccine and help in understanding of the MAYV pathology.This project is intended to assess the immune response elicited by this vaccine candidate in animal models, supplying the required information for the development of this vaccine and increasing the knowledge about the Mayaro fever immunology.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA MOTA, MANLIO TASSO; VEDOVELLO, DANILA; ESTOFOLETE, CASSIA; MALOSSI, CAMILA DANTAS; ARAUJO, JOAO PESSOA, JR.; NOGUEIRA, MAURICIO LACERDA. Complete Genome Sequence of Mayaro Virus Imported from the Amazon Basin to Sao Paulo State, Brazil. GENOME ANNOUNCEMENTS, v. 3, n. 6, p. 1-pg., 2015-11-01. (14/05600-9, 13/21719-3)

OLIVEIRA MOTA, MANLIO TASSO; VEDOVELLO, DANILA; ESTOFOLETE, CASSIA; MALOSSI, CAMILA DANTAS; ARAUJO, JR., JOAO PESSOA; NOGUEIRA, MAURICIO LACERDA. Complete Genome Sequence of Mayaro Virus Imported from the Amazon Basin to Sao Paulo State, Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 3, n. 6, NOV-DEC 2015. (14/05600-9, 13/21719-3)

DE OLIVEIRA MOTA, MANLIO TASSO; RIBEIRO, MILENE ROCHA; VEDOVELLO, DANILA; NOGUEIRA, MAURCIO LACERDA. Mayaro virus: a neglected arbovirus of the Americas. FUTURE VIROLOGY, v. 10, n. 9, p. 1109-1122, 2015. (14/05600-9, 13/21719-3)

ESTOFOLETE, CASSIA FERNANDA; OLIVEIRA MOTA, MANLIO TASSO; VEDOVELLO, DANILA; NUNES DE GONGORA, DELZI VINHA; MAIA, IRINEU LUIZ; NOGUEIRA, MAURICIO LACERDA. Mayaro fever in an HIV-infected patient suspected of having Chikungunya fever. Revista da Sociedade Brasileira de Medicina Tropical, v. 49, n. 5, p. 648-652, SEP-OCT 2016. (13/21719-3, 14/05600-9)

DE OLIVEIRA MOTA, MANLIO TASSO; COSTA, VIVIAN VASCONCELOS; SUGIMOTO, MICHELLE AMANTEA; GUIMARAES, GEORGIA DE FREITAS; QUEIROZ-JUNIOR, CELSO MARTINS; MOREIRA, THAIANE PINTO; DE SOUSA, CARLA DAIANE; SANTOS, FRANCIELE MARTINS; QUEIROZ, VICTORIA FULGENCIO; PASSOS, INGREDY; et al. In-depth characterization of a novel live-attenuated Mayaro virus vaccine candidate using an immunocompetent mouse model of Mayaro disease. SCIENTIFIC REPORTS, v. 10, n. 1, MAR 24 2020. (14/05600-9, 13/21719-3)

MOTA, MANLIO T. DE O.; AVILLA, CLARITA M. S.; NOGUEIRA, MAURICIO L.. Mayaro virus: a neglected threat could cause the next worldwide viral epidemic. FUTURE VIROLOGY, v. 14, n. 6, p. 4-pg., 2019-06-01. (14/05600-9, 13/21719-3)