Evaluation of macrophage phenotype upon hepcidin expression and iron influx: a possible local role in adipose tissue.

• Grant number: 14/04986-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2014
• End date: July 31, 2015
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Principal Investigator: Alessandra Gambero
• Grantee: Ana Paula Timóteo Ferreira
• Host Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil

Abstract

Iron levels alterations are associated to obesity. In addition, adipose tissue has an iron overload during obesity, as well as, hepcidin expression was altered in adipose tissue macrophages. The exact role of these alterations is not fully understood. Thus, by using human monocyte differentiated in leptin presence as a model of adipose tissue macrophage, we intend to study the ability of this cells to express hepcidin, incorporate iron and contribute to local inflammation in adipose tissue.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GOTARDO, ERICA MARTINS FERREIRA; DE MORAIS, THAINA RODRIGUES; FERREIRA, ANA PAULA TIMOTEO; CARIA, CINTIA RABELO E PAIVA; RIBEIRO, MARCELO LIMA; GAMBERO, ALESSANDRA. Deferoxamine Interference in Fibro-inflammation: Additional Action in Control of Obese Adipose Tissue Dysfunction. CURRENT DRUG TARGETS, v. 24, n. 8, p. 9-pg., 2023-01-01. (14/04986-0, 18/03665-7)