Immunocellular profile (dendritic cells, neutrophils, macrophages, lymphocytes T and B)in granulomatous reaction in orphan and re-emerging diseases

• Grant number: 14/10083-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2014
• End date: August 31, 2016
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Vera Luiza Capelozzi
• Grantee: Marcel de Oliveira Moscardi
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Sarcoidosis and chronic hypersensitivity pneumonia, granulomatous lung diseases of non-infectious origin, as well as other infectious granulomatous diseases such as tuberculosis, histoplasmosis, and paracoccidioidomycosis are currently associated with high mortality and morbidity. This is related to the low efficiency of therapeutic options and pulmonary parenchymal abnormalities associated with pulmonary granuloma formation. The granulomatous reaction is associated with an intense inflammatory response with activation of fibroblasts and deposition of extracellular matrix (ECM). The fact is that, especially in the case of sarcoidosis, the pathogenic mechanisms of these diseases are unknown, and about disease susceptibility and clinical course. The search for a better understanding and possible solutions to the limitations of the treatment of sarcoidosis and other granulomatosis is critical for public health programs of the American continent mainly in Brazil. Thus, the goal of this project is to study the matrix and cellular immune responses in granuloma formation in infectious lung disease or not, the main focus being the study of sarcoidosis, besides studying a possible viral involvement in its etiology. (AU)