The role of muscle damage in muscle protein synthesis modulation

• Grant number: 14/19594-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: March 16, 2015
• End date: March 15, 2016
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Ugrinowitsch
• Grantee: Felipe Romano Damas Nogueira
• Supervisor: Stuart M. Phillips
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: McMaster University, Canada
• Associated to the scholarship: 12/24499-1 - The role of the magnitude of muscle damage in hypertrophic responses, BP.DR

Abstract

It is not yet established whether muscle damage plays an important role in the chronic hypertrophic process in response to resistance training (RT) in humans, since the magnitude of muscle damage is significantly attenuated throughout training sessions. Therefore, the aim of this study is investigate if the attenuation of muscle damage during training sessions reduces the rate of muscle protein synthesis (MPS) during 10 weeks of RT in young men. It was realized functional evaluations and muscle biopsies (before and after training bouts in the first, third and last training weeks) that will allow the analysis of the different magnitudes of muscle damage and their associated MPS responses. The extent of damage will be assessed by quantification of maximum torque, sarcomeral Z-line integrity, disrupted desmin and ultrasound echo intensity (all of these procedures were not included in this project as they will be already be collected and analyzed in Brazil before the internship in Canada). The rate of MPS will be quantified through oral ingestion of deuterated water and muscle biopsies. Our hypothesis is that greater magnitudes of muscle damage (which will occur at the beginning of the RT period) will induce a higher rate of MPS and with the course of training, the magnitude of damage will progressively be attenuated and the rate of MPS will also gradually decrease. (AU)

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DAMAS, FELIPE; PHILLIPS, STUART M.; LIBARDI, CLEITON A.; VECHIN, FELIPE C.; LIXANDRAO, MANOEL E.; JANNIG, PAULO R.; COSTA, LUIZ A. R.; BACURAU, ALINE V.; SNIJDERS, TIM; PARISE, GIANNI; et al. Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage. JOURNAL OF PHYSIOLOGY-LONDON, v. 594, n. 18, p. 5209-5222, SEP 15 2016. (14/19594-0, 12/24499-1, 13/21218-4)

DAMAS, F.; NOSAKA, K.; LIBARDI, C. A.; CHEN, T. C.; UGRINOWITSCH, C.. Susceptibility to Exercise-Induced Muscle Damage: a Cluster Analysis with a Large Sample. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, v. 37, n. 8, p. 633-640, JUL 2016. (14/19594-0, 12/24499-1, 13/21218-4)

FOCHI, A. G.; DAMAS, F.; BERTON, R.; ALVAREZ, I; MIQUELINI, M.; SALVINI, T. F.; LIBARDI, C. A.. Greater eccentric exercise-induced muscle damage by large versus small range of motion with the same end-point. BIOLOGY OF SPORT, v. 33, n. 3, p. 285-289, 2016. (12/24499-1, 11/22122-5, 14/19594-0, 13/21218-4)

DAMAS, FELIPE; UGRINOWITSCH, CARLOS; LIBARDI, CLEITON A.; JANNIG, PAULO R.; HECTOR, AMY J.; MCGLORY, CHRIS; LIXANDRAO, MANOEL E.; VECHIN, FELIPE C.; MONTENEGRO, HORACIO; TRICOLI, VALMOR; et al. Resistance training in young men induces muscle transcriptome-wide changes associated with muscle structure and metabolism refining the response to exercise-induced stress. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 118, n. 12, p. 2607-2616, DEC 2018. (14/19594-0, 16/24259-1, 17/04299-1, 12/24499-1, 13/21218-4, 18/13064-0)

DAMAS, F.; LIBARDI, C. A.; UGRINOWITSCH, C.; VECHIN, F. C.; LIXANDRAO, M. E.; SNIJDERS, T.. Early- and later-phases satellite cell responses and myonuclear content with resistance training in young men (vol 13, e0191039, 2018). PLoS One, v. 13, n. 2, p. 1-pg., 2018-02-14. (16/24259-1, 13/21218-4, 12/24499-1, 14/19594-0)

DAMAS, FELIPE; LIBARDI, CLEITON A.; UGRINOWITSCH, CARLOS; VECHIN, FELIPE C.; LIXANDRAO, MANOEL E.; SNIJDERS, TIM; NEDERVEEN, JOSHUA P.; BACURAU, ALINE V.; BRUM, PATRICIA; TRICOLI, VALMOR; et al. Early- and later-phases satellite cell responses and myonuclear content with resistance training in young men. PLoS One, v. 13, n. 1, JAN 11 2018. (14/19594-0, 16/24259-1, 12/24499-1, 13/21218-4)

DAMAS, FELIPE; LIBARDI, CLEITON A.; UGRINOWITSCH, CARLOS. The development of skeletal muscle hypertrophy through resistance training: the role of muscle damage and muscle protein synthesis. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 118, n. 3, p. 485-500, MAR 2018. (14/19594-0, 16/24259-1, 17/04299-1, 12/24499-1, 13/21218-4)

DAMAS, FELIPE; PHILLIPS, STUART M.; LIXANDRAO, MANOEL E.; VECHIN, FELIPE C.; LIBARDI, CLEITON A.; ROSCHEL, HAMILTON; TRICOLI, VALMOR; UGRINOWITSCH, CARLOS. Early resistance training-induced increases in muscle cross-sectional area are concomitant with edema-induced muscle swelling. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 116, n. 1, p. 49-56, JAN 2016. (14/19594-0, 12/24499-1, 13/21218-4)

DAMAS, FELIPE; PHILLIPS, STUART M.; LIBARDI, CLEITON A.; VECHIN, FELIPE C.; LIXANDRAO, MANOEL E.; JANNIG, PAULO R.; ROSCHEL, HAMILTON; COSTA, LUIZ A. R.; TRICOLI, VALMOR; UGRINOWITSCH, CARLOS. Muscle Damage Over A Resistance-training Period: Repeated Bout Effect Analysed Through Direct And Indirect Markers. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 48, n. 5, p. 1-pg., 2016-05-01. (12/24499-1, 13/21218-4, 14/19594-0)