Qualitative and quantitative analysis of the extracellular matrix remodelling in granulomatous processes through the expression of Th1(IL-12, TNF-alpha and IFN-gamma) by immunohistochemistry

• Grant number: 14/19921-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2014
• End date: November 30, 2016
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Vera Luiza Capelozzi
• Grantee: Vinicius de Miranda Martinho
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Sarcoidosis and hypersensitivity chronic pneumonia, noninfectious granulomatous disease, as well as other infectious granulomatous diseases such as tuberculosis, histoplasmosis and paracoccidioidomycosis are currently associated with high mortality and morbidity. This is related to the low efficiency of therapeutic options and pulmonary parenchymal abnormalities associated with pulmonary granuloma formation. The granulomatous reaction is associated with an intense inflammatory response with activation of fibroblasts and deposition of extracellular matrix(ECM). Mainly in the case of sarcoidosis, the pathogenic mechanisms, the susceptibility and the clinical course of these diseases are little known. The search for a better understanding and possible solutions to the limitations of the treatment of sarcoidosis and other granulomatosis is critical to public health programs of the American continent, mainly to Brazil. Thus, the purpose of this project is to study the matrix and cellular immune responses in granuloma formation in infectious lung disease or not, focusing on the sarcoidosis in addition to studying a possible viral involvement in its etiology.