Metabolic profile and oocyte competence in the in vitro development of embryos of dairy cows repeater breeder submitted to drying and subsequent induction of lactation

• Grant number: 14/19460-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2015
• End date: March 31, 2018
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Reproduction
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Pietro Sampaio Baruselli
• Grantee: Rodolfo Daniel Mingoti
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The increase in human population growth generates constant concerns regarding the global food production. For increasing milk production is necessary that herds has adequate reproductive efficiency. In this scenario, repeat breeders (RB; cows that did not become pregnant after four or more consecutive services during a single lactation) are associated to low reproductive efficiency and large economic losses. Despite its importance, there is limited scientific information on the metabolic profile and oocyte competence of female RB, which hinders the improvement of strategies to reduce the prevalence of these females in herds. There are reports that the highest consumption of foods associated with decreased milk production in mid and late lactation results in positive energy balance and increased plasma concentrations of glucose and insulin. This framework induces peripheral insulin resistance, which in, can result in decreased oocyte quality, lower embryo survival and consequently, reduce reproductive efficiency of female RB. Thus, the objective of this study is to assess: 1) the establishment of the framework of peripheral insulin resistance and in vitro production of embryos from cows RB; 2) the impact of drying on peripheral insulin resistance in vitro production of embryos; 3) the induction of lactation on peripheral insulin resistance and in vitro production of embryos. The hypothesis of this study suggests that repeater breeder cows submitted to drying and subsequent induction of lactation reverse the RPI table and, consequently, improve oocyte quality and in vitro production of embryos. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MINGOTI, Rodolfo Daniel. Oocyte and embryo quality, hormonal and metabolic profile in repeat breeder cows submitted to drying and induction of lactation. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.