| Grant number: | 15/01792-3 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | June 01, 2015 |
| End date: | May 31, 2016 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Marcela Sorelli Carneiro Ramos |
| Grantee: | Carolina Victória da Cruz Junho |
| Host Institution: | Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil |
Abstract The immunological system consists of an array of cells and molecules distributed throughout the organism, its function is to recognize antigens or molecular structures, generating an effective response in the pathogens destruction or inactivation. It can also act via the complement system (CS) which is the primary humoral component of the inflammatory processes. It is well known that cardiac tissue is target of the immunological system and some cardiovascular diseases (CVD) are preceded by general or local inflammation, contributing directly to the remodeling and the heart tropism. It is known that kidney failure may result in the development of systemic inflammation and it can reach the cardiac tissue. The response of the tissue response may be initiated by Toll-like receptors (TLR), which are recognizers pathogen-associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs) or also by complement system. During the whole inflammatory process, the complement component C3a is released in abundance and binds to C3aR1 receptor, which is involved in TLRs activation. The objective of this study is to evaluate the role of the complement system in cardiac hypertrophy induced by renal ischemia, and the involvement of TLR 4. For this TLR4 knockout mice will be used as a model of renal ischemia and reperfusion, through the occlusion of the left renal pedicle for 60', followed by reperfusion for 8, 12 or 15 days. It is expected that the results of this study might contribute to a better understanding of the cross-talk between kidney, heart and related inflammatory processes. | |
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