Neuronal dynamics of cardiac control during postnatal development in cavies (Galea spixii, Wangler, 1831)

• Grant number: 14/50442-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2015
• End date: March 31, 2016
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Francisco Javier Hernandez Blazquez
• Grantee: Aliny Antunes Barbosa Lobo Ladd
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The heart becomes natural morphological and functional changes during postnatal development and growth of people aged over 65 years, creates the need to thoroughly understand the mechanisms involved in this process. The heart has a dual autonomic innervation (sympathetic and parasympathetic) which is modulated by central periganglionar neurons located in the brain and brain stem, which can also be altered by age, which would entail the establishment of arrhythmia right central origins and/or autonomic . Therefore, this research will analyze in the light of stereo-logical design different iponents of neurapraxia cardiac control: the core components paraventricular nucleus and nucleus ambiguous and the autonomic components stellate ganglion and cardiac plexus in caveis, used here as a development model postnatal development maturation and aging in the nervous system. Techniques are modern and accurate use of 3D stereology quantification associated with bio-imaging techniques and immune histochemistry for the identification of different markers of neuronal life proliferation, apoptosis and plenipotentiary cycle. Hoping thereby generate results that can be useful in understanding the neuronal dynamics in the regions mentioned in cardiac control, and consequently contribute to advances in knowledge of the morphological basis of the effects of postnatal development in the central and autonomic cardiac control, which can be useful in veterinary medicine to cardiology, which commonly deal with animals body surface area greater than that of laboratory animals, such as rats and mice. (AU)