Characterization of IL17 expression in the gastrointestinal tract in response to different nutrients: its potential role as an incretin

• Grant number: 15/03121-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: June 01, 2015
• End date: June 30, 2020
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Licio Augusto Velloso
• Grantee: Carina Solon da Silva
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/12611-0 - Molecular mechanisms involved in pancreatic beta cell disfunction and dead in diabetes mellitus: strategies for the inhibition of these processes and restoration of the insular mass, AP.TEM
• Associated scholarship(s): 16/03713-6 - Evaluation and characterization of insulin secretion and glucose metabolism in response to IL 17 in human and mice, BE.EP.PD

Abstract

Since the discovery of Th17 lymphocyte, this has been associated with the coordination of the physiologically inflammatory immune responses that provide protection against pathogens at the mucosal interface. Disorders of this population of T lymphocytes are related to various autoimmune diseases with inflammatory bowel disease, psoriasis, among others.My PhD project revealed a different function to Th17. As we study the expression of IL17 in the intestine, we observed that this cytokine mRNA is expressed more in the ileum, and the gene expression increases in response to food passage, especially a diet high in saturated fat. This increase in gene expression causes a current increase of IL17 and insulin secretion demonstrating incretin effect.Knockout animals had hyperglycemia for IL17R at birth, insulin deficiency and malformations of the pancreatic islets which also demonstrates an important role in embryonic development of the pancreas. It is noteworthy that the data are confidential and are under submission to international journal (FAPESP 2010 / 52378-9 process).  So the aim of this project is to investigate in more detail the role of incretin IL17. (AU)