Neurogenic bladder in children and adolescents: family impact and biomarkers

• Grant number: 14/23949-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2015
• End date: May 31, 2016
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Carlo Camargo Passerotti
• Grantee: Rafael Ulysses de Azevedo
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Neurogenic bladder (NB) is a term used to describe changes in bladder function, which are caused by neurological disorders, congenital or acquired disorders, and it often improves the condition of the subjacent disease morbidity. The causes and presentation of neurogenic bladder in children are different from adults. In most cases, the pediatric neurogenic bladder is congenital and for a long time myelomeningocele was the main cause, but with technological advancement it was discovered that the hidden spina bifida is the most common cause. Since there are different treatment modalities necessary for appropriate care of these children, it is important to evaluate the quality of children and adolescents' life with NB, observing their lifestyle, acceptance, adaptation and difficulties of treatment; as well as evaluating that the care, of both children and parents, is performed correctly. It is necessary also to deepen the studies about urinary biomarkers for early diagnosis and also a more appropriate treatment for patients with NB . This study consists of a descriptive qualitative research, where items such as the quality of life of families and children with neurogenic bladder, the nursing care provided to them and the analysis of biomarkers NGF and BDNF collected will be evaluated in urine samples from the patients and the correlation between these biomarkers with neurogenic bladder type, age, weight, height and type of treatment used. The study will be conducted on all patients with neurogenic bladder, less than 18 years old, and their legally responsible, are being assisted at the Clinic of Urology, Hospital das Clinicas, Medical School, University of São Paulo (HC-USP).