Sunlight effects on tryptophan metabolism in skin cells

• Grant number: 15/08763-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2015
• End date: February 28, 2017
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Ana Campa
• Grantee: Maysa Braga Barros Silva
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Several benefits of exposure sunlight have been described, as the direct relation with psychological well-being. Moreover, the light is related to the maintenance of homeostasis and skin metabolismo. In the skin, tryptophan (TRP) is metabolized to biologically active compounds and it is believed that serotonin synthesis, metabolite of TRP, in phototherapy is part of the remission mechanisms of depression in patients with seasonal mood disorder. It is also known, the TRP metabolites have the ability to control the synthesis of melanin in the skin. Furthermore, sunlight induces directly the expression and activity of TDO, enzyme that catalyzes the conversion of TRP in kynurenine (KYN), in bactéria, efeito que ainda não foi estudado em células de mamíferos. With that, the objective of this study is evaluate the ability of sunlight to modulate the TRP metabolism in skin cells and in three-dimensional model reconstructed skin. This study will be assisted by Profs. Silvya SM Engler, Silvia BM Barros and Ernani Pinto Jr. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Maysa Braga Barros. Effect of light on tryptophan metabolism in melanocytes and melanomas.. 2017. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.